The Wine-Dark Sea
This is the planning site for my D&D 4e campaign. It will be taking place in the Forgotten Realms setting, as I have some little familiarity with the setting. Needless to say Baldur’s Gate, Icewind Dale, and Neverwinter Nights make this a very attractive campaign setting from a familiarity point of view. They offer a model for how to create a storyline that is very local in the early stages and to work outwards from that.
After that, take a look at your wiki. There is some more helpful info there.